Modeling Cell-to-Cell Spread of HIV-1 with Nonlocal Infections
نویسندگان
چکیده
منابع مشابه
Macrophages and Cell-Cell Spread of HIV-1
Macrophages have been postulated to play an important role in the pathogenesis of HIV-1 infection. Their ability to cross the blood-brain barrier and their resistance to virus-induced cytopathic effects allows them to serve as reservoirs for long-term infection. Thus, exploring the mechanisms of virus transmission from macrophages to target cells such as other macrophages or T lymphocytes is ce...
متن کاملHIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell
Cell-to-cell spread of HIV, a directed mode of viral transmission, has been observed to be more rapid than cell-free infection. However, a mechanism for earlier onset of viral gene expression in cell-to-cell spread was previously uncharacterized. Here we used time-lapse microscopy combined with automated image analysis to quantify the timing of the onset of HIV gene expression in a fluorescent ...
متن کاملA mathematical model of cell-to-cell spread of HIV-1 that includes a time delay.
We consider a two-dimensional model of cell-to-cell spread of HIV-1 in tissue cultures, assuming that infection is spread directly from infected cells to healthy cells and neglecting the effects of free virus. The intracellular incubation period is modeled by a gamma distribution and the model is a system of two differential equations with distributed delay, which includes the differential equa...
متن کاملDendritic Cell Dysfunction: A Key to HIV Spread and Persistence
Dendritic cells (DC) are both widely dispersed in the body and are potent activators of effector immune response, which stresses their important role in HIV infection [1,2]. DCs are present at sites of HIV entry, the oral and vaginal mucosa [3,4] or circulating blood [5], and at sites of preferential HIV infection and maintenance in the lymph nodes. It has been shown that HIV-infected DCs media...
متن کاملCell-to-Cell Spread of Retroviruses
Viruses from several families use direct cell-to-cell infection to disseminate between cells. Retroviruses are a relatively recent addition to this list, and appear to spread cell-to-cell by induction of multimolecular complexes termed virological synapses that assemble at the interface between infected and receptor-expressing target cells. Over the past five years, detailed insight into the ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Complexity
سال: 2018
ISSN: 1076-2787,1099-0526
DOI: 10.1155/2018/2139290